![]() ![]() Probes may be deposited or directly synthesized on either a silica chip, a glass slide, in a gel-matrix, or on a bead. Since their inception in 1989, the underlying technology and DNA probe content applied to microarrays has diversified considerably. ![]() While all three technologies generate high volume data that require serious consideration of methods of analysis, this overview focuses on analysis of data from the most widely used platform, microarrays. Technologies such as serial analysis of gene expression (SAGE) or, more recently, massively parallel signature sequencing (MPSS Brenner et al., 2000), provide alternative means to measure mRNA abundance. Analysis of Expression Data: An Overview Transcriptome profiling, the simultaneous measurement and analysis of expression changes in thousands of RNAs, has been enabled largely by microarray technology (Schena et al., 1995). ![]()
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